Multi-Omics and Epigenetic Clocks: Offerings, Turnaround, and Price

Multi-Omics and Epigenetic Clocks: Offerings, Turnaround, and Price

Imagine looking at health through five different windows.

• Whole-genome sequencing shows the DNA you were born with.
• Methylation testing looks at chemical tags that help control how genes work.
• Microbiome testing studies the tiny organisms living in and on your body.
• Metabolomics measures small molecules made by your body.
• Proteomics measures proteins that may show what your body is doing right now.

Together, these tests are called multi-omics. They promise a deeper picture of health, aging, disease risk, nutrition, and recovery.

But there is an important truth: more data does not always mean better care. The best programs connect test results to clear medical decisions, repeat testing, and a clinician who can explain what matters.

This article reviews public offerings from clinics, physician-led programs, direct-to-consumer companies, and specialty laboratories. Prices and services were checked on August 18, 2026. Prices can change, and some programs add fees for blood draws, consultations, supplements, shipping, or travel.

Quick Summary

• Whole-genome sequencing is the most mature of these services. A one-time test can be useful when it finds a genetic result that changes screening, medication choices, or family testing.
• Epigenetic clocks are promising but should not be treated as a diagnosis. A result showing that someone is “older” or “younger” than their true age does not yet tell a doctor which treatment to prescribe.
• Microbiome tests can support nutrition experiments and research, but there is no single definition of a “perfect” microbiome.
• Metabolomics and proteomics can show useful patterns, but many commercial reports remain closer to advanced wellness testing than standard medical care.
• Public prices range from about $279 for a gut test to $19,000 per year for a high-end executive program.
• The strongest model is usually genome once, dynamic tests later, and regular clinical measures throughout.

What the Main Test Types Measure

Whole-genome sequencing

Whole-genome sequencing reads nearly all of a person’s DNA. It may identify:

• Inherited disease risks
• Carrier status
• Pharmacogenomic markers
• Some cancer-related variants
• Polygenic risk estimates
• Nutrition, exercise, or medication-related traits

The genome usually does not change. This means it often makes sense to sequence it once and update the interpretation as new science becomes available.

However, the depth of sequencing matters. Human Longevity advertises 30-times clinical-grade sequencing, while Biome advertises 3-times whole-genome sequencing and clearly states that its product is for wellness and is not clinical grade. Biome also says that clinical-level use requires deeper testing to confirm rare or disease-causing variants. (humanlongevity.com)

DNA methylation and epigenetic clocks

DNA methylation is one way the body helps control gene activity. An epigenetic clock uses methylation patterns to estimate biological age or the pace of aging.

Some tests report:

• A general biological age
• Age acceleration
• Pace of aging
• Immune system age
• Organ-specific age
• Inflammation-related measures

These tests are appealing because they may reflect lifestyle, stress, illness, and the environment. Yet experts warn that one reading can be affected by illness, stress, tissue type, sample handling, and the specific clock used. A 2025 analysis concluded that current clocks do not yet have the reliability, clear cutoffs, and clinical action steps needed for routine individual medical decisions. (pmc.ncbi.nlm.nih.gov)

Microbiome profiling

A gut microbiome test may measure:

• Which bacteria, fungi, viruses, or other organisms are present
• The number of different organisms
• Microbial genes
• Microbial activity
• Predicted pathways
• Some links to food and nutrient processing

Some tests use DNA sequencing. Others, such as Viome, focus heavily on RNA activity, which is meant to show what microbes are doing rather than only which microbes are present. (viome.com)

The microbiome changes with diet, medicine, stress, sleep, travel, and illness. Different companies may also produce different results from the same sample. A National Institute of Standards and Technology study found important differences among commercial gut microbiome testing services. (pmc.ncbi.nlm.nih.gov)

Metabolomics

Metabolomics measures small molecules in blood, urine, or other samples. These molecules may include:

• Amino acids
• Organic acids
• Fatty acids
• Energy-related compounds
• Hormone breakdown products
• Markers linked to inflammation or oxidative stress

Metabolomics can provide a closer look at current body chemistry than DNA testing. However, food, fasting, exercise, medicine, time of day, temperature, and sample delay can all change the results. This makes careful sample handling very important. (pmc.ncbi.nlm.nih.gov)

Proteomics

Proteomics measures proteins in blood or other body fluids. Proteins are active workers in the body. They may reflect:

• Inflammation
• Immune activity
• Organ stress
• Blood vessel health
• Brain health
• Cancer-related signals
• Metabolic changes

Some research platforms can measure thousands of proteins from a small blood sample. For example, SomaLogic advertises an 11,000-protein assay from 55 microliters of sample through its clinical laboratory and authorized sites. (somalogic.com)

The challenge is that most large protein signatures are still being studied. Relatively few proteomic discoveries have moved into routine medical care. (pmc.ncbi.nlm.nih.gov)

Clinic and Provider Survey

Human Longevity

Human Longevity offers one of the clearest public whole-genome sequencing prices in the United States.

Offerings

Its public Genomics for All program includes:

• Whole-genome sequencing
• Pharmacogenomics
• Cancer and cardiovascular risk insights
• Carrier status
• Longevity and metabolic traits
• A physician-ready report
• Secure data access
• Annual re-analysis
• One year of access to its artificial intelligence application

The public price is $599 one time. The company says the sample is collected at home with saliva, processed in its own Clinical Laboratory Improvement Amendments, or CLIA, certified laboratory, and returned in about six to eight weeks. (humanlongevity.com)

Executive programs

Human Longevity also offers larger programs:

• Executive Health: $8,000 per year
• 100+ Care: $12,000 per year
• 100+ Concierge: $19,000 per year

The executive program combines whole-genome sequencing, whole-body imaging, more than 120 blood biomarkers, proteomics, artificial intelligence analysis, and clinician review. The more expensive programs add continuing monitoring, more imaging, specialist consultations, and concierge care. (humanlongevity.com)

Report depth and updates

The public WGS report includes disease-risk findings, pharmacogenomics covering more than 200 medications, and a physician-ready PDF. The executive program describes more than 150 gigabytes of health data per client each year. (humanlongevity.com)

The genome itself is tested once. Human Longevity says it will re-analyze the same genome each year as research and algorithms improve. (humanlongevity.com)

Important limitation

Older Health Nucleus materials listed microbiome assessment as part of an annual longevity program. Current public Human Longevity pages emphasize whole-genome sequencing, imaging, blood biomarkers, proteomics, and artificial intelligence. Patients should ask whether microbiome and methylation testing are included in the exact program being offered. (healthnucleus.com)

Northwestern Medicine Human Longevity Clinic

Northwestern Medicine offers a more traditional physician-led model.

Offerings

The clinic publicly lists:

• Epigenetic clocks
• Molecular aging analysis
• Artificial intelligence-based analysis
• Body composition testing
• Heart and vascular testing
• Physical function testing
• Cognitive and sensory testing
• Retinal imaging
• Exercise and nutrition consultations

The initial visit is a half-day evaluation. A follow-up visit takes place several weeks later. The clinic also lists repeat testing at six months, followed by another review with the care team. (longevity.nm.org)

Report depth and care integration

The patient receives a customized report, a physician discussion, and consultations with an exercise physiologist and registered dietitian. This is important because the program connects molecular results to movement, nutrition, strength, and daily habits.

The clinic does not publish a simple public price list or name all laboratory partners on its public pages. Patients should ask:

• Which methylation clock is used?
• How many methylation sites are tested?
• Which tests are repeated at six months?
• Is proteomics included now, or only planned?
• What happens if a result is abnormal?

Northwestern has said that its research and clinical programs are adding technology capable of measuring thousands of proteins. (nm.org)

Biongevity

Biongevity is an international longevity clinic and subscription program. Its public package page is one of the few that lists all five areas in the same offering.

Public packages

Biongevity Core: $369 per month

The Core package lists:

• Longevity genetics
• Gut microbiome snapshot
• Epigenetic aging proxies
• Glucose and insulin
• Cortisol
• Sex hormones
• Vitamins
• Artificial intelligence coaching
• Monthly summaries

Biongevity Precision: $699 per month

This package adds:

• 30-times whole-genome sequencing
• Pharmacogenomics
• Telomere measurement
• Inflammation markers
• Testing at baseline and again in six to twelve months
• Quarterly expert review

Biongevity Elite: $999 per month

This package lists:

• 100-times whole-genome sequencing
• Multi-omics microbiome testing
• Metabolomics
• Advanced epigenetic clocks
• Immune and metabolic aging signals
• Oxidative stress markers
• Targeted proteomics
• Optional cell-free DNA and RNA sequencing
• Testing at baseline and again in three to six months
• Monthly protocol updates
• Quarterly executive reports

(biongevity.com)

Sample handling and laboratory partners

The public package page does not clearly name the laboratory partners, sequencing platform, sample collection methods, or exact report formats. That is a major buying question.

Biongevity appears to be based around international and United Arab Emirates services. A United States customer should confirm:

• Where samples are collected
• Where they are tested
• Whether the laboratory is CLIA or College of American Pathologists accredited
• Whether results are medical or wellness reports
• Whether a United States physician reviews the findings
• Whether taxes, shipping, consultations, and supplements are included

The program is attractive because it offers continuing updates. It is also the type of program that requires the most careful due diligence.

TruAge and Other Epigenetic Age Services

TruAge through Instalab

Instalab offers a TruAge biological age test.

Public details include:

• Price: $569 sale price, with a listed price of $711
• Sample: Blood or finger-prick blood
• Laboratory: TruDiagnostic
• Turnaround: About two weeks
• Report: Biological age, aging rate, and the age of 11 organ systems
• Review: Physician-reviewed report and game plan

(instalab.com)

This is a deeper offering than a simple “one number” age test. Still, it remains a risk and tracking tool, not a diagnosis.

Longevity One

Longevity One describes a blood-based test sent to an accredited United States laboratory. It says the analysis covers more than 900,000 methylation sites and includes several clocks, such as Horvath, Hannum, and DunedinPACE. It reports a turnaround of four to six weeks and recommends retesting every six to twelve months. (longevityone.ge)

10X Health System

The 10X “Methylation Genetic Test” is easy to misunderstand.

It is not an epigenetic age test. It tests 27 genes involved in pathways related to methylation, vitamin D, glutathione, free radicals, and neurotransmitters. It is a genetic test about inherited tendencies, not a measure of how old the body appears.

Public prices are:

• Methylation Genetic Test: $599
• Precision Genetic Test: $1,299

The test uses an at-home saliva sample. Results are usually ready within a few weeks after the laboratory receives the sample. The company describes the test as a once-in-a-lifetime test because genes do not change. The Precision package includes three reports totaling more than 490 pages. (shop.10xhealthsystem.com)

This is a good example of why buyers should ask, “Are you testing methylation genes, or are you measuring DNA methylation age?”

Viome

Viome is a direct-to-consumer platform rather than a full medical clinic, but it offers one of the broadest public microbiome programs.

Offerings

• Gut Intelligence Test: $279
• Full Body Intelligence Test: $399

The Gut test uses stool. The Full Body test uses:

• Stool
• Saliva
• Finger-prick blood

The Full Body test reports more than 70 health scores and more than 370 food recommendations. Viome says its gut analysis studies microbial activity and about 400 pathways. Results are usually available in two to three weeks after the samples reach its CLIA-certified laboratory. (viome.com)

Report depth

The reports cover areas such as:

• Gut health
• Immune health
• Energy
• Inflammation
• Metabolism
• Oral health
• Brain and cognitive health
• Biological age

The platform recommends foods, supplements, probiotics, and prebiotics. Viome says that formulas can change when a customer retests. It recommends retesting every six months. (viome.com)

Sample handling

The user collects the samples at home and mails them to the laboratory. Viome says it may reissue one part of a kit at no cost if a stool, blood, or saliva sample fails quality checks. (viome.com)

Limitation

Viome’s RNA-based approach is interesting, but its food and supplement recommendations should not be treated as a substitute for testing for celiac disease, inflammatory bowel disease, infection, bleeding, or other medical problems.

Metabolomics Services

Metabolomics OMX through True Health Labs

True Health Labs sells a Metabolomics OMX test processed by Diagnostic Solutions Laboratory.

Public details include:

• Price: $359
• Samples: Urine and plasma
• Turnaround: Seven to ten business days
• Measures: Organic acids and amino acids
• Fasting: Follow the kit instructions
• Extra costs: Blood draw fees may apply
• Restrictions: Not available in several states, including New York, New Jersey, Massachusetts, and Rhode Island

(truehealthlabs.com)

This is a specialty laboratory test, not a full physician-led longevity program. It may produce a detailed report, but the buyer must confirm who will interpret it and how the results will change care.

SoLongevity AGE360

The SoLongevity AGE360 program lists:

• GrimAge biological age
• Epigenetic radar analysis
• Metabolomics
• Blood testing
• Glutathione and NAD testing
• A longevity physician consultation
• A personal longevity book

The clinic does not publish a simple price on the page and asks customers to request details. (solongevity.com)

Proteomics Services

Human Longevity

Human Longevity includes proteomics in its $8,000 executive program, along with whole-genome sequencing, imaging, blood biomarkers, artificial intelligence analysis, and clinician review. The public page does not name the specific proteomics platform or laboratory partner. (humanlongevity.com)

Gabriel Diagnostics

Gabriel offers organ-specific biological age testing through blood protein analysis.

Public details include:

• Price: $500 to $800
• Turnaround: Three to six weeks
• Sample: Plasma
• Depth: About 5,000 proteins
• Report: Age estimates for the heart, liver, brain, kidneys, immune system, and gut

The ordering path points to TruDiagnostic. Gabriel does not clearly name a separate laboratory partner on its own service page. (askgabriel.com)

SomaScan

SomaScan is a laboratory technology rather than a typical consumer clinic. Its clinical laboratory advertises 7,000- and 11,000-protein assays. The 11,000-protein test uses 55 microliters of sample and is performed through a CLIA-certified and College of American Pathologists-accredited laboratory. (somalogic.com)

When a clinic offers “proteomics,” ask:

• How many proteins are measured?
• Is the test based on SomaScan, Olink, mass spectrometry, or another method?
• Is it a clinical test or a research-use assay?
• Are results compared with a validated reference group?
• Is the report showing individual proteins or only a combined score?
• Who will act on an abnormal result?

Whole-Genome Alternatives

Biome

Biome offers a lower-cost whole-genome wellness product:

• Price: $349 one time
• Sample: At-home saliva
• Laboratory: CLIA- and College of American Pathologists-accredited United States laboratories
• Turnaround: Two to three weeks after the lab receives the sample
• Depth: 3-times whole-genome sequencing
• Report: More than 70 traits
• Retesting: Usually not needed because new panels can be run from the same stored sequence

Biome clearly states that the test is not clinical grade and should not be used to diagnose disease. (biome.you)

This may be useful for wellness and education. It should not replace confirmatory clinical testing when a doctor needs to act.

Public Price Ranges

The following ranges reflect public examples, not fixed industry prices.

The prices above come from public listings by Human Longevity, Biome, Instalab, Viome, True Health Labs, Gabriel, Biongevity, and specialty laboratory providers. (humanlongevity.com)

Common Bundling Strategies

1. Genome once, updates forever

This is the clearest model.

The patient pays once for whole-genome sequencing. The company then adds new reports as science advances. Human Longevity includes annual re-analysis. Biome says new traits and panels can be added without another sample. (humanlongevity.com)

2. Dynamic tests every six to twelve months

Methylation, microbiome, metabolomics, and proteomics measure changing biology. Providers often bundle them into a baseline test and a later test.

Examples include:

• Northwestern Medicine: repeat testing at six months
• Viome: retesting every six months
• Longevity One: retesting every six to twelve months
• Biongevity Precision: baseline and six-to-twelve-month testing
• Biongevity Elite: baseline and three-to-six-month testing

(nm.org)

3. Annual blood testing with optional add-ons

Function Health illustrates another popular model. Its membership costs $365 per year and includes more than 160 laboratory tests, testing twice a year, and optional imaging and specialty tests. It is not a full multi-omics program, but it shows how companies use a low annual membership to create a continuing health record. (functionhealth.com)

4. Test plus coaching and products

Some companies include:

• Personalized food plans
• Supplement recommendations
• Probiotics
• Custom supplement packs
• Exercise or nutrition coaching
• Artificial intelligence chat
• Physician consultations

This may improve follow-through. However, it also creates a possible conflict of interest when the same company sells the products it recommends. Ask whether the recommendation engine is independent and whether the clinician can suggest a lower-cost alternative.

5. Executive “one-day” programs

High-end programs bundle many tests into one visit:

• WGS
• Whole-body MRI
• Heart imaging
• Blood biomarkers
• Proteomics
• Body composition
• Physician review

This is convenient, but convenience does not prove better health outcomes. The value depends on whether the findings lead to appropriate prevention and follow-up.

Sample Handling: The Detail Many Buyers Miss

Saliva

Saliva is simple and convenient. It is used for:

• WGS
• Genetic methylation pathway tests
• Some oral microbiome tests

The main risks are low sample volume, food or drink contamination, and poor collection technique.

Blood

Blood is common for:

• Epigenetic clocks
• Proteomics
• Metabolomics
• Clinical biomarkers
• Transcriptomics

Blood tests may require:

• Fasting
• A morning collection
• A clinic blood draw
• A finger-prick device
• Careful temperature control
• Rapid processing

Stool

Stool is used for microbiome testing. It is sensitive to:

• Time before stabilization
• Temperature
• Water contamination
• Collection method
• Recent antibiotics
• Diet
• Stool consistency

A microbiome test is only as useful as the sample and the comparison group behind the report. International microbiome experts recommend careful collection, preservation, reporting, and clear limits on interpretation. (pmc.ncbi.nlm.nih.gov)

Urine and plasma

Metabolomics services often use both urine and plasma. The exact collection time, fasting state, tube type, shipping temperature, and time to processing can affect results. (pmc.ncbi.nlm.nih.gov)

Clinical Utility: What Can Really Change Care?

Whole-genome sequencing

Whole-genome sequencing has the clearest path to clinical use when it finds a well-established, actionable result.

Possible actions may include:

• Earlier screening
• Confirmatory testing
• Genetic counseling
• Family testing
• A change in medication choice or dose
• More careful monitoring for a known inherited risk

Polygenic risk scores and wellness traits are different. They usually describe probability, not certainty. A high score does not mean a person will develop a disease, and a low score does not remove ordinary risk.

Epigenetic clocks

Epigenetic clocks may be useful for:

• Research studies
• Comparing groups
• Tracking possible changes over long periods
• Supporting a broader health review

They should not be used alone to prescribe supplements, hormones, drugs, or other “anti-aging” treatments. Current research points to problems with single-timepoint readings, changing methylation patterns, tissue differences, and unclear treatment thresholds. (pmc.ncbi.nlm.nih.gov)

Microbiome testing

Microbiome testing may be useful for:

• Studying diet and digestive symptoms
• Tracking a personal nutrition experiment
• Research
• Supporting a clinician’s broader evaluation

It should not be used alone to diagnose or treat serious disease. There is still limited evidence that a commercial microbiome report can improve medical decisions. Experts also point to major differences in sample handling, sequencing, reference groups, and data analysis. (pmc.ncbi.nlm.nih.gov)

Metabolomics

Metabolomics may help show patterns that ordinary blood testing misses. It can be especially interesting when a clinician has a clear question about nutrient use, energy pathways, or unusual symptoms.

The main limitation is that many findings are not specific. A metabolite may change because of diet, medicine, exercise, sleep, infection, or sample handling. A promising pattern is not the same as a proven diagnosis. (pmc.ncbi.nlm.nih.gov)

Proteomics

Proteomics may eventually help with:

• Organ-specific risk
• Early disease signals
• Treatment response
• Aging research
• Drug development

Today, many large protein panels remain research tools. Results may be valuable for tracking, but most do not yet have widely accepted treatment cutoffs. Different platforms may also produce different results. (pmc.ncbi.nlm.nih.gov)

How to Integrate Multi-Omics Into a Real Care Plan

A useful care plan should follow this order.

Step 1: Start with a question

Do not begin with, “I want every test.”

Begin with:

• Do I have a family history of early heart disease?
• Could a medicine work differently for me?
• Why are my energy levels low?
• Am I improving after changing my diet and exercise?
• Do I have a clear reason to study gut function?
• Do I need help understanding an unusual clinical result?

Step 2: Build a basic medical baseline

Advanced testing should sit beside ordinary health measures, not replace them.

A clinician may review:

• Blood pressure
• Cholesterol and ApoB
• Blood sugar and hemoglobin A1c
• Kidney and liver function
• Blood counts
• Weight and waist size
• Sleep
• Strength
• Fitness
• Mood
• Family history

These measures often lead to clearer treatment decisions than a single biological-age number.

Step 3: Use WGS for durable information

If choosing WGS, ask for:

• Average coverage
• Variant confirmation rules
• Clinical laboratory credentials
• Genetic counseling
• Raw data access
• Re-analysis policy
• How medically important results are reported
• Whether family testing is supported

A 3-times wellness genome should not be treated the same as a 30-times clinical genome. (biome.you)

Step 4: Standardize repeat testing

For changing tests, use the same:

• Laboratory
• Sample type
• Time of day
• Fasting plan
• Collection method
• Medication and supplement record
• Reporting platform

For microbiome testing, record recent antibiotics, major diet changes, illness, and travel. For metabolomics, record fasting, exercise, and the timing of the blood draw.

Step 5: Turn results into three to five actions

A report should end with a short plan.

For example:

1. One change to food.
2. One change to exercise.
3. One sleep goal.
4. One standard clinical test to repeat.
5. One follow-up visit.

A 500-page report is not a care plan unless it changes what the patient does next.

Step 6: Use hard outcomes to judge progress

Do not judge success only by a lower biological age score.

Also track:

• Blood pressure
• ApoB or other lipid measures
• Hemoglobin A1c
• Fitness
• Strength
• Sleep
• Symptoms
• Body composition
• Medication response
• Daily function

If a molecular result improves but the patient feels worse or standard risk markers worsen, the care plan needs review.

Step 7: Retest at a sensible pace

There is no universal schedule, but a practical approach is:

• WGS: Once, with annual re-analysis if included
• Epigenetic age: About six to twelve months, not every few weeks
• Microbiome: About three to six months after a major diet or treatment change
• Metabolomics: About three to six months after an intervention
• Proteomics: Often six to twelve months, unless a doctor or research study calls for earlier testing
• Routine clinical biomarkers: Often three to six months when tracking a treatment change

These are practical planning ranges, not official medical rules. The right schedule depends on the test, the clinical question, and the person’s health.

Questions to Ask Before Paying

Before buying a multi-omics package, ask:

1. What exact decision will this test change?
2. Is the test for diagnosis, wellness, research, or treatment monitoring?
3. Which laboratory performs the test?
4. Is the laboratory CLIA certified and, when relevant, College of American Pathologists accredited?
5. What sample is needed, and how should it be stored?
6. Does the report show raw data, individual markers, or only a score?
7. Which clock or algorithm is used?
8. Has the test been validated in people like me?
9. Who reviews the results?
10. What happens if the result is abnormal?
11. What is the retesting schedule?
12. Are updates included, or do they require another payment?
13. Are supplements or other products being sold based on the result?
14. Can I delete my data and request destruction of my sample?
15. Will my regular doctor receive a clear summary?

The United States Food and Drug Administration warns that direct-to-consumer tests vary in evidence and that many laboratory-developed tests do not receive the same independent review as FDA-authorized tests. It also advises people to discuss health-related results with a qualified health professional. (fda.gov)

Conclusion

Multi-omics testing is moving from research laboratories into longevity clinics, private medical practices, and home testing kits.

The strongest current use is not chasing the lowest biological age. It is using the right test for the right question:

• Use whole-genome sequencing for durable inherited information.
• Use methylation testing as a cautious tracking tool, not a diagnosis.
• Use microbiome testing to support careful nutrition experiments, not to label every digestive problem.
• Use metabolomics when a clinician has a clear biochemical question.
• Use proteomics as an emerging view of active biology, with careful attention to validation.

The best program is not the one with the most numbers. It is the one that gives a clear baseline, uses credible laboratories, explains uncertainty, repeats the right tests at the right time, and turns results into simple actions.

**More information can help people make better choices. But information becomes health care only when it leads to sound decisions, careful follow-up, and measurable improvement.